Computational Analysis of the Binding Specificities of PH Domains

Table 3

Comparison of ligand-protein contacts in 5 PH domain-inositol phosphate complexes.

		Contact surface area (Å^2)			Normalized complementarities
		Legitimate contacts	Illegitimate contacts	Complementarities
1B55	P1-O3	31.3	10.6	20.7	0.17
	P3-O3	85.0	16.0	69.0	0.65
	P4-O3	86.8	17.9	68.9	0.76
	P5-O3	81.6	19.7	61.9	0.57
1FGY	P1-O3	31.0	23.8	7.2	0.06
	P3-O3	89.6	21.8	67.8	0.61
	P4-O3	114.8	8.5	106.3	1.00
	P5-O3	104.5	11.1	93.4	0.80
1MAI	P1-O3	44.0	0.5	43.5	0.34
	P4-O3	83.0	17.8	65.2	0.55
	P5-O3	85.8	0.3	85.5	0.72
1BTN	P1-O3	33.6	0	33.6	0.27
	P4-O3	69.4	23.5	45.9	0.43
	P5-O3	72.6	0	72.6	0.68
1FAO	P1-O3	34.8	18.1	16.7	0.13
	P3-O3	82.9	23.1	59.8	0.55
	P4-O3	102.1	3.1	99.0	0.98
	P5-O3	45.0	20.9	24.1	0.20