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BioMed Research International
Volume 2015, Article ID 793257, 31 pages
Review Article

Animal Models for the Study of Rodent-Borne Hemorrhagic Fever Viruses: Arenaviruses and Hantaviruses

Department of Molecular Virology, Virology Division, United States Army Medical Research Institute of Infectious Diseases, Fort Detrick, MD 21702, USA

Received 13 March 2015; Accepted 14 June 2015

Academic Editor: Kevin M. Coombs

Copyright © 2015 Joseph W. Golden et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Supplementary Material

Hamsters represent an important small animal model to study a variety of fields including metabolism, carcinogenesis/tumorigenesis, inflammation and infection and disease. However, hamster models are often overlooked by many investigators, resulting in a lower popularity when compared to mouse and rat models. In some cases, as with New World hantaviruses, hamsters represent the only known small animal model of human disease caused by these viruses, elevating their importance as a tool to understand human disease pathogenesis. Still, the dearth of hamster-specific reagents to study many aspects of disease pathogenesis and immunological processes, when compared to the overwhelming abundance of mouse, rat, human, and nonhuman primate reagents, has made a direct comparison of human disease and hamster disease, difficult. In rare instances, commercial vendors such as have begun selling hamster-specific reagents. Unfortunately, this is more the exception than the rule as most reagents used to study hamsters are cross-reactive mouse, rat and human reagents that have been identified by trial and error. In the following table, we have attempted to consolidate those, predominantly immunologically related, reagents that we and others have used in the hamster model.

  1. Supplementary Materials