Animal Models for the Study of Rodent-Borne Hemorrhagic Fever Viruses: Arenaviruses and Hantaviruses

Table 4

Prototypical hantavirus strains and their origin.

Virus	Strain	Origin	Passage history	Animal model	Notes, type of model	Reference
HTNV	76–118	Korea (1978), Apodemus agrarius	8 P Apodemus agrarius	Apodemus agrarius	Persistent infection model	[187]
			5 P Apodemus agrarius, 3-4 P A549 cells, 2-18 P Vero E6	ICR suckling mice	MCM, pathogenesis	[177, 184–186, 188–190]
PUUV	Hällnäs	Sweden (1981), Clethrionomys glareolus	2 P Clethrionomys glareolus	Clethrionomys glareolus, NHP	Persistent infection model, pathogenesis	[191, 192, 207]
	K27	U.S.S.R (1983), Clethrionomys glareolus	5 P Vero E6	Syrian hamster	MCM, pathogenesis	[208]
DOBV	Slovenia	Yugoslavia (1992), Apodemus flavicollis	5 P Vero E6	NMRI suckling mice, Syrian hamster	MCM, pathogenesis	[209]
SEOV	80–39		3 P Wistar rats, 8 P Vero E6	Syrian hamster, Lewis rat, and Norway rat	MCM, persistent infection model	[210]
	SR-11	Japan (1983), Rat	5–7 P Vero E6	Syrian hamster, Norway rat	MCM, persistent infection model	[211]
ANDV	Chile-9717869	Chile (1997), Oligoryzomys longicaudatus	4–7 P Vero E6	Syrian hamster	MCM, pathogenesis	[197, 212]
SNV	CC107	United States (1995), Peromyscus maniculatus	3-4 P Vero E6	Syrian hamster	MCM, pathogenesis	[213]
	77734	United States (2000), Peromyscus maniculatus	2 P Peromyscus maniculatus	Peromyscus maniculatus, NHP	Pathogenesis	[203]
MAP	97021050	Venezuela (1997), Oecomys bicolor	4 P Vero E6	Syrian hamster	Pathogenesis	[205]
PHV	Prospect Hill I	United States (1982), Microtus pennsylvanicus	1 P Microtus pennsylvanicus, Serial P Vero E6	NHP	Pathogenesis	[214]