Protective Effect of Intravenous High Molecular Weight Polyethylene Glycol on Fatty Liver Preservation

Figure 2

Hepatic and mitochondrial injuries after cold ischemia and reperfusion. PEG 35 administration decreases aspartate aminotransferase (AST) (a), alanine aminotransferase (ALT) (b), and glutamate dehydrogenase (GLDH) levels after 2 hours of ex vivo perfusion. Ctr 2: liver procurement and ex vivo perfusion; UW: livers preserved in UW preservation solution for 24 h at 4°C and then subjected to 2 h of normothermic ex vivo perfusion; PEG 35: rats treated intravenously with PEG 35 (10 mg/kg) and then subjected to 24 h cold ischemia followed by 2 h of normothermic ex vivo perfusion. Data represent mean ± SEM. versus Ctr 2; versus UW.

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