Protective Effect of Intravenous High Molecular Weight Polyethylene Glycol on Fatty Liver Preservation

Figure 3

Effects of PEG 35 on eNOS activation and vascular resistance. PEG 35 pretreatment activates eNOS and decreases vascular resistance: densitometric analysis of eNOS/β-actin (a) and vascular resistance (b) after 120 min of normothermic reperfusion. Ctr 2: liver procurement and ex vivo perfusion; UW: livers preserved in UW preservation solution for 24 h at 4°C and then subjected to 2 h of normothermic ex vivo perfusion; PEG 35: rats treated intravenously with PEG 35 (10 mg/kg) and then subjected to 24 h cold ischemia followed by 2 h of normothermic ex vivo perfusion. Data represent mean ± SEM. versus Ctr 2; versus UW.

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