Protective Effect of Intravenous High Molecular Weight Polyethylene Glycol on Fatty Liver Preservation

Figure 5

Effect of PEG 35 on MAPKs. PEG 35 reduces p38-MAPK activation whereas it has no effect on JNK and ERK phosphorylation. Densitometric analysis of phosphorylated p38/β-actin (a), phosphorylated JNK/β-actin (b), and phosphorylated ERK/β-actin (c). Ctr 2: liver procurement and ex vivo perfusion; UW: livers preserved in UW preservation solution for 24 h at 4°C and then subjected to 2 h of normothermic ex vivo perfusion; PEG 35: rats treated intravenously with PEG 35 (10 mg/kg) and then subjected to 24 h cold ischemia followed by 2 h of normothermic ex vivo perfusion. Data represent mean ± SEM. versus Ctr 2; versus UW.

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