Hepatocyte-Specific Ablation of PP2A Catalytic Subunit α Attenuates Liver Fibrosis Progression via TGF-β1/Smad Signaling
PP2Acα knockout alleviated liver injury induced by chronic CCl4 administration. (a) PP2Ac protein levels in the livers of knockout (Ppp2cαfl/fl/AlbCre+) and control (Ppp2cαfl/fl and AlbCre+) mice were determined by Western blot analysis (left panel) and immunohistochemical staining (right panel) using an antibody detecting both PP2Acα and PP2Acβ. Magnification, ×400. Bar, 200 μm. (b) PP2A phosphatase activity of protein extracts from the mice liver tissues. Each value is mean ± SD (), . (c, d) Serum alanine aminotransferase (ALT) and aspartate aminotransferase (AST) levels in the knockout and control mice 48 h after intraperitoneal injection with 2 mg/kg CCl4 three times a week for 5 weeks. Each value is mean ± SD (), .
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