Hepatocyte-Specific Ablation of PP2A Catalytic Subunit α Attenuates Liver Fibrosis Progression via TGF-β1/Smad Signaling
PP2Acα ablation diminished the serum level of TGF-β1 and its downstream signal transduction. (a) Quantification of serum TGF-β1 level by ELISA in the control and PP2Acα knockout mice chronically treated with CCl4 for 5 weeks. Values are means ± SD, . . (b) Western blot analysis of phospho-Smad2 (p-Smad2), total Smad2 (Smad2), phospho-Smad3 (p-Smad3), and total Smad3 (Smad3) expression levels in the livers from the control and PP2Acα knockout mice treated chronically with CCl4 for 5 weeks.
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