The Genetic and Environmental Factors for Keratoconus

Table 4

List of the identified genomic loci through linkage studies.

Population	Location	Mode of inheritance	Gene	Reference
Australian	1p36.23-36.21	Autosomal dominant		[83]
Ecuadorian	2q13-q14.3	Autosomal dominant		[84]
European, Arabic, Caribbean African	2p24			[85]
Italian	3p14-q13	Autosomal dominant		[86]
Caucasian, Southern Italian	5q14.3-q.21.1	Autosomal dominant		[87, 88]
Caucasian, Hispanic	5q23.2			[89]
Southern Italian	5q32-q33			[87]
Australian	8q13.1-q21.11	Autosomal dominant		[83]
Caucasian, Hispanic	9q34			[89]
Ecuadorian	13q32	Autosomal dominant	DOCK9	[90–92]
Southern Italian	14q11.2			[87]
Caucasian, Hispanic	14q11.2			[89]
Multiethnic	14q24.3			[93]
Southern Italian	15q2.32			[87]
Northern Irish	15q22.33-24.2	Autosomal dominant	miR-184	[94–97]
Finnish	16q22.3-q23.1	Autosomal dominant		[98]
Pakistani	17p13	Autosomal recessive		[99]
Ecuadorian	20p13-p12.2			[84]
Australian, Tasmania	20q12	Autosomal dominant		[100]