Structure-Function Based Molecular Relationships in Ewing’s Sarcoma

<table class="figure-group"><tr class="fig-image" id="a"><td><object data="https://static.hindawi.com/articles/bmri/volume-2015/798426/figures/798426.fig.001a.svgz" name="798426.fig.001a" type="image/svg+xml"></object></td></tr><tr class="fig-caption"><td><b>(a) </b>EWS isoform 2 (656 AAs)</td></tr><tr class="fig-image" id="b"><td><object data="https://static.hindawi.com/articles/bmri/volume-2015/798426/figures/798426.fig.001b.svgz" name="798426.fig.001b" type="image/svg+xml"></object></td></tr><tr class="fig-caption"><td><b>(b) </b>EWS/FLI1 type 1 (476 AAs)</td></tr><tr class="fig-image" id="c"><td><object data="https://static.hindawi.com/articles/bmri/volume-2015/798426/figures/798426.fig.001c.svgz" name="798426.fig.001c" type="image/svg+xml"></object></td></tr><tr class="fig-caption"><td><b>(c) </b>EWS/ATF1 type 2 (432 AAs)</td></tr><tr class="fig-image" id="d"><td><object data="https://static.hindawi.com/articles/bmri/volume-2015/798426/figures/798426.fig.001d.svgz" name="798426.fig.001d" type="image/svg+xml"></object></td></tr><tr class="fig-caption"><td><b>(d) </b>EWS/ZSG long B isoform (609 AAs)</td></tr></table>

<div>The IPD of native protein EWS isoform 2 (656 AAs) and isoforms of EWS oncogenic proteins EWS/ FLI1 (476 AA), EWS/ATF1 (432 AA), and EWS/ZSG long B isoform (609 AA) were estimated by Predictors IUPred [<a href="/journals/bmri/2015/798426/#B3">3</a>], DisEMBL [<a href="/journals/bmri/2015/798426/#B5">5</a>], RONN [<a href="/journals/bmri/2015/798426/#B7">7</a>], and PONDR [<a href="/journals/bmri/2015/798426/#B8">8</a>]. Higher IPD score is equivalent to higher disorder tendency estimated by the Predictor. (a) EWS isoform 2 (656 AAs). (b) EWS/FLI1 type 1 (476 AAs). (c) EWS/ATF1 type 2 (432 AAs). (d) EWS/ZSG long B isoform (609 AAs).</div>

BioMed Research International

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Figure 1

Figure 1: Structure-Function Based Molecular Relationships in Ewing’s Sarcoma 