Atrial Fibrillation and Fibrosis: Beyond the Cardiomyocyte Centric View

Figure 8

Myofibroblast as a possible cell target for antiarrhythmic therapy. (a) Reentrant excitation on myofibroblasts coated cardiomyocytes monolayer. Top: colour coded reentrant propagation. Bottom optical action potential traces. (b) UDCA hyperpolarizes MFBs membrane potential only. Red circles: cardiomyocytes monolayers. Yellow circles: heterocellular monolayers. Green circles: MFB monolayers. . (c) Topographical images obtained by scanning ion conductance microscopy of a MFB embedded in a monolayer. (d) Effect of UDCA on impulse propagation velocity in myofibroblast coated with cardiomyocytes strands (modified with permission from [9]).

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