iTRAQ-Based Quantitative Proteomic Analysis Identified HSC71 as a Novel Serum Biomarker for Renal Cell Carcinoma

Table 2

List of differentially expressed proteins in ccRCC compared to control group.

Accession	Description	Score	Coverage	Ratio
Proteins upregulated in ccRCC compared with control group
P11142	Heat shock cognate 71 kDa protein	31.11	4.80%	3.07
P02763	Alpha-1-acid glycoprotein 1	251.48	40.80%	2.087
Q16777	Histone H2A type 2-C	164.19	49.61%	1.984
P68871	Hemoglobin subunit beta	320.13	60.54%	1.942
Q00532	Cyclin-dependent kinase-like 1	20.04	1.96%	1.828
P02748	Complement C9	984.63	41.86%	1.815
P02787	Serotransferrin	1689.45	61.46%	1.775
P07360	Complement component C8 gamma chain	466.53	61.39%	1.753
P02768	Serum albumin	2997	82.76%	1.705
P69905	Hemoglobin subunit alpha	140.62	26.76%	1.697
P25311	Zinc-alpha-2-glycoprotein	275.61	35.91%	1.673
P01031	Complement C5	2686.11	49.16%	1.646
P68363	Tubulin alpha-1B chain	127.08	6.21%	1.605
P00738	Haptoglobin 1 alpha	922.06	59.61%	1.58
Q12931	Heat shock protein 75 kDa	43.68	1.99%	1.546
Q8NG11	Tetraspanin-14	34.11	2.96%	1.518
Proteins downregulated in ccRCC compared with control group
Q96KN2	Beta-Ala-His dipeptidase	142.84	12.62%	0.651
Q5T686	Arginine vasopressin-induced protein 1	45.27	4.08%	0.643
P01614	Ig kappa chain V-II region Cum	83.17	33.04%	0.627
P55056	Apolipoprotein C-IV	189.85	40.94%	0.622
Q16610	Extracellular matrix protein 1	643.87	34.44%	0.614
Q96KK5	Histone H2A type 1-H	177.42	50.00%	0.606
P14618	Pyruvate kinase PKM	47.37	3.95%	0.582
P33908	Mannosyl-oligosaccharide	60.74	4.75%	0.495
P01019	Angiotensinogen	620.93	28.45%	0.426
O60814	Histone H2B type 1-K	67.21	15.87%	0.419
Q15166	Serum paraoxonase/lactonase 3	138.75	11.86%	0.415
P68431	Histone H3.1	24.05	5.15%	0.377
P01815	Ig heavy chain V-II region COR	12.87	5.83%	0.37
P62805	Histone H4	171.24	45.63%	0.353