Research Article
iTRAQ-Based Quantitative Proteomic Analysis Identified HSC71 as a Novel Serum Biomarker for Renal Cell Carcinoma
Table 2
List of differentially expressed proteins in ccRCC compared to control group.
| Accession | Description | Score | Coverage | Ratio |
| Proteins upregulated in ccRCC compared with control group | P11142 | Heat shock cognate 71 kDa protein | 31.11 | 4.80% | 3.07 | P02763 | Alpha-1-acid glycoprotein 1 | 251.48 | 40.80% | 2.087 | Q16777 | Histone H2A type 2-C | 164.19 | 49.61% | 1.984 | P68871 | Hemoglobin subunit beta | 320.13 | 60.54% | 1.942 | Q00532 | Cyclin-dependent kinase-like 1 | 20.04 | 1.96% | 1.828 | P02748 | Complement C9 | 984.63 | 41.86% | 1.815 | P02787 | Serotransferrin | 1689.45 | 61.46% | 1.775 | P07360 | Complement component C8 gamma chain | 466.53 | 61.39% | 1.753 | P02768 | Serum albumin | 2997 | 82.76% | 1.705 | P69905 | Hemoglobin subunit alpha | 140.62 | 26.76% | 1.697 | P25311 | Zinc-alpha-2-glycoprotein | 275.61 | 35.91% | 1.673 | P01031 | Complement C5 | 2686.11 | 49.16% | 1.646 | P68363 | Tubulin alpha-1B chain | 127.08 | 6.21% | 1.605 | P00738 | Haptoglobin 1 alpha | 922.06 | 59.61% | 1.58 | Q12931 | Heat shock protein 75 kDa | 43.68 | 1.99% | 1.546 | Q8NG11 | Tetraspanin-14 | 34.11 | 2.96% | 1.518 |
| Proteins downregulated in ccRCC compared with control group | Q96KN2 | Beta-Ala-His dipeptidase | 142.84 | 12.62% | 0.651 | Q5T686 | Arginine vasopressin-induced protein 1 | 45.27 | 4.08% | 0.643 | P01614 | Ig kappa chain V-II region Cum | 83.17 | 33.04% | 0.627 | P55056 | Apolipoprotein C-IV | 189.85 | 40.94% | 0.622 | Q16610 | Extracellular matrix protein 1 | 643.87 | 34.44% | 0.614 | Q96KK5 | Histone H2A type 1-H | 177.42 | 50.00% | 0.606 | P14618 | Pyruvate kinase PKM | 47.37 | 3.95% | 0.582 | P33908 | Mannosyl-oligosaccharide | 60.74 | 4.75% | 0.495 | P01019 | Angiotensinogen | 620.93 | 28.45% | 0.426 | O60814 | Histone H2B type 1-K | 67.21 | 15.87% | 0.419 | Q15166 | Serum paraoxonase/lactonase 3 | 138.75 | 11.86% | 0.415 | P68431 | Histone H3.1 | 24.05 | 5.15% | 0.377 | P01815 | Ig heavy chain V-II region COR | 12.87 | 5.83% | 0.37 | P62805 | Histone H4 | 171.24 | 45.63% | 0.353 |
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