BioMed Research International / 2015 / Article / Tab 1

Review Article

Congenital Corneal Anesthesia and Neurotrophic Keratitis: Diagnosis and Management

Table 1

Aetiopathogenesis of neurotrophic keratitis.

InfectionsHerpes simplex
Herpes zoster
Leprosy [16]

Corneal pathologiesDystrophies
(i) Lattice
(ii) Granular

Iatrogenic injuryContact lens wear
Surgeries
Laser-assisted in situ keratomileusis [17]
Corneal incision [18]
Lamellar and penetrating keratoplasty

Topical medicationsAnaesthetics
Timolol
Betaxolol
Trifluridine
Sulfacetamide
Diclofenac sodium [19]

Toxic substancesChemical burns
Exposure to oleoresin capsicum pepper spray [20]
Exposure to hydrogen sulfide (H2S) [21]

Cranial nerve V palsyTrigeminal neuralgia surgery
Neoplasm
Aneurysm
Facial trauma [10]
Congenital: 
(i) Riley-Day syndrome
(ii) Möbius corneal hypoesthesia
(iii) Goldenhar syndrome
(iv) Familial corneal hypesthesia
(v) (Familial trigeminal anesthesia)
(vi) Congenital insensitivity to pain with anhidrosis

Systemic diseasesDiabetes
Vitamin A deficiency
Multiple sclerosis

MiscellaneousIncreasing age
Adie’s syndrome [22]

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