Effects of Surgical and Dietary Weight Loss Therapy for Obesity on Gut Microbiota Composition and Nutrient Absorption

Figure 5

Faecal bile acids alterations six months after laparoscopic sleeve gastrectomy (LSG). OPLS-DA coefficient plot showing the increase or decrease in concentration for each of the bile acids identified by targeted profiling. The model compares 6 months post-LSG with preoperative values. The coefficient along the -axis is a measure of both the magnitude and direction of change of bile acid concentrations. indicates which metabolites contribute significantly to class discrimination (pre- to post-LSG; P(corr) > 0.75 and P(corr) < −0.75) corresponding to the color scale code shown on the left hand. Error bars derived from calculation of Jack-knifing uncertainty measures. (b) Suggested impact of LSG on extrahepatic bile acid circulation based on the presented data.

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