|
Interaction with host cell | Virus type | Method | References |
|
Facilitating virus entry | BPV | E6 facilitates the BPV entry by clathrin interaction | [35] |
|
Antiapoptotic effect | HPV | E6 promotes Bax degradation, resulting in an antiapoptotic effect | [114, 115] |
|
Binding to E6AP ubiquitin ligase | HPV | E6 expressed in E. coli and insects binds to E6AP ubiquitin ligase | [50, 95, 116, 117] |
|
Binding to DNA | HPV | E6 expressed in E. coli binds with DNA | [118–120] |
|
Cell immortalization | HPV | E6 promotes p53 degradation and cell immortalization | [121–123] |
|
Epigenetic downregulation of p53 | HPV | E6 expressed in baculovirus induces hypoacetylation of p53 | [124, 125] |
HPV | E6 expressed in E. coli interacts with p300/CBP, reducing p53 levels | [126] |
BPV | E6 interacts with p300/CBP, reducing p53 levels | [51] |
|
Disruption of mitotic apparatus | HPV | E6 transfected using LXSN vectors | [29, 30, 127] |
|
Malignant transformation in cell culture | HPV | Complete genome of HPV-16 transfected in NIH 3T3 cells | [45, 88, 128–130] |
|
Interaction with paxillin | BPV | E6 of BPV-1 interacts with paxillin, reducing the focal adhesion | [34, 69, 72, 131, 132] |
|
Repressor activity of telomerases | HPV | E6 induces the hTERT expression, reducing the telomerase activity | [96, 133, 134] |
|
Immune depletion | HPV | E6 expressed in yeast reduces the levels of interferon regulatory factor-3 | [135] |
|