The Skin as an Early Expression of Malignancies in the Neonatal Age: A Review of the Literature and a Case Series

Figure 1

Skin involvement in the leukemia cutis, in a newborn on the first day of life. Randomly distributed subcutaneous nodules (arrows) on the chest (particularly in (a)) and on the trunk (c) with bluish infiltrates on the whole body surface (c) and particularly on the chest and the arm in (a) and (b). The blood cell rose until 167300/mcl, with prevalence of monocytes, low platelets count, and low hemoglobin levels. Infective pathologies have been excluded. The peripheral smear permitted the diagnosis of AML with positivity for CD45, CD33, CD14, CD13 heterogeneous, CD11b, and CD16 dull (AML-4). Genetic analysis revealed t(8;16)(p11;p13). After starting chemotherapy with aracytin, idarubicin, cytarabine, and etoposide, he died at 2 months of life.