The Skin as an Early Expression of Malignancies in the Neonatal Age: A Review of the Literature and a Case Series

Figure 5

Nodular lesions diffused on the body in a term baby with alveolar rhabdomyosarcoma. Particular image of the chest and right arm (a) and the legs (b). An incisional biopsy of the cutis showed aggregates of atypical small spindle cells interrupted by fibrovascular septae and collagen bands resembling the lung alveoli. Bone marrow biopsy and total body CT scan demonstrated the presence of pulmonary, pleural, and pericardial metastasis. Chemotherapy was started, without a clinical improvement. The baby died at 26 days of life because of renal insufficiency and heart failure.

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