Altered Expression Levels of MMP1, MMP9, MMP12, TIMP1, and IL-1 as a Risk Factor for the Elevated IOP and Optic Nerve Head Damage in the Primary Open-Angle Glaucoma Patients

Figure 1

Analysis of the mRNA expression levels. (a) Overall expression level of in the POAG patients compared to control group without any type of glaucoma (value after subtraction of the control group presented as fold change ); expression levels with regard to genotype in POAG patients group: (b) MMP1; (c) MMP9; (d) MMP12; (e) IL-1β; (f) TIMP1. Data presented as fold change compared to the wild type genotype (whose expression was taken as 1). Error bars represent standard deviations (SD). . (). There was no difference in genotypes distribution between patients with OAG and control subjects (). MMP1: 1G/1G = 17; 1G/2G = 17; 2G/2G = 16 MMP9: C/C = 22; C/T = 23; T/T = 5 MMP12: A/A = 23; A/G = 23; G/G = 4 IL-1β: C/C = 17; C/T = 17; T/T = 16 TIMP1: T/T = 17; T/C = 17; C/C = 16.

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