Preparation of Silica Nanoparticles Loaded with Nootropics and Their In Vivo Permeation through Blood-Brain Barrier

Table 1

Concentrations of drug-loaded silica nanocarriers permeated through the BBB to brain in comparison with drugs in bulk (n.d. = not detected).

Drug substance	Concentration [ng/mL] in 100 mg of brain tissue
	Bulk	Extraction of nanocarriers	Direct injection of tissue with nanoparticles
Piracetam	2.8–1.0	0.25–0.01	440–275
Pentoxifylline	6000–2000	2.5–0.75	44000–
Pyridoxine	n.d	n.d	—

Predicted based on the ratio bulk/direct injection of piracetam.