Research Article
Trichostatin A-Mediated Epigenetic Transformation of Adult Bone Marrow-Derived Mesenchymal Stem Cells Biases the In Vitro Developmental Capability, Quality, and Pluripotency Extent of Porcine Cloned Embryos
Table 3
Effect of the TSA-mediated epigenomic modulation of MSCs on the cytological quality of cloned pig embryos assessed by TUNEL assay.
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TSA: trichostatin A; MSC: mesenchymal stem cell; TUNEL: terminal deoxynucleotidyl transferase- (TdT-) mediated dUTP (2′-deoxyuridine-5′-triphosphate) nick-end labelling; DAPI: 4′,6-diamidino-2-phenylindole; SD: standard deviation; DCI: dead cell index. Values with different large superscript letters (A and B) within the same column denote very highly significant differences ( < 0.005; ANOVA followed by Tukey’s HSD post hoc test). Number of replicates = 6. |