Cortical Structural Connectivity Alterations in Primary Insomnia: Insights from MRI-Based Morphometric Correlation Analysis

Figure 3

Between-group comparison of structural covariance seeded from the right primary visual cortex (PVC). (a) Structural covariance maps in healthy controls (HC) and patients with primary insomnia (PI). Seed region is colored in blue. (b) Increased right PVC-cortical network covariance in PI. Patients showed trends of increased covariance between the right PVC and the medial motor areas (PCL/SMA) and the left cuneus, the right vmPFC, and the right posterior insula (, uncorrected). (c) Decreased right PVC-cortical network covariance in PI. Patients showed trends of decreased covariance between the right PVC and the lateral PFC, the IFGoperc, the IPC, the LOC, the dmPFC, and the left STC (, uncorrected). Scatter plots illustrate slope differences in selected vertices, where adjusted cortical thickness values and regression lines are shown in red for patients and in blue for controls.

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