Cortical Structural Connectivity Alterations in Primary Insomnia: Insights from MRI-Based Morphometric Correlation Analysis

Figure 6

Between-group comparison of structural covariance seeded from the left olfactory cortex (OLF). (a) Structural covariance maps in healthy controls (HC) and patients with primary insomnia (PI). Seed region is colored in blue. (b) Increased left OLF-cortical network covariance in PI. Patients showed trends of increased correlations of the left OLF with the left precentral gyrus, the medial motor areas (PCL/SMA), the PHG, the medial occipital lobes, the right ACC, the right ITC, the lowermost part of the right postcentral gyrus, the right anterior insula, and the bilateral precuenus/PCC (, uncorrected). (c) Decreased left OLF-cortical network covariance in PI. Patients showed trends of decreased correlations of the left OLF with the lateral PFC, the IPC, the dmPFC and the LTC (, uncorrected). Scatter plots illustrate slope differences in selected vertices, where adjusted cortical thickness values and regression lines are shown in red for patients and in blue for controls.

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