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BioMed Research International
Volume 2015, Article ID 817615, 7 pages
Research Article

Pentraxin-3 Predicts Long-Term Cardiac Events in Patients with Chronic Heart Failure

1Shanghai Institute of Cardiovascular Diseases, Zhongshan Hospital, Fudan University, Shanghai 200032, China
2Department of Cardiology, Yinzhou People’s Hospital, Medical School of Ningbo University, Ningbo 315040, China
3Clinical Laboratory Center, Yinzhou People’s Hospital, Medical School of Ningbo University, Ningbo 315040, China

Received 23 July 2015; Revised 13 September 2015; Accepted 5 October 2015

Academic Editor: Hua Zhu

Copyright © 2015 Haibo Liu et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


The aim of this study was to investigate the long-term prognostic value of pentraxin-3 (PTX3) in patients with chronic heart failure (CHF). 377 patients were prospectively followed up for 3 years to determine cardiac events including cardiac death or rehospitalization for worsening heart failure. The plasma PTX3 levels were significantly higher in CHF patients than in healthy subjects (), and they increased with advancing New York Heart Association (NYHA) Functional Classification (). Plasma PTX3 levels in CHF patients with cardiac events were significantly higher than in event-free patients (). We determined the normal upper limit of plasma PTX3 levels from the mean + 2 SD value of 64 control subjects (3.64 ng/mL). A Kaplan-Meier analysis revealed that patients with increased PTX3 (≥3.64 ng/mL) were at a higher risk for cardiac events than those without increased PTX3 (). A multifactorial Cox proportional hazards model showed that increased PTX3 (≥3.64 ngImL) was an independent risk factor for cardiac events in CHF patients (hazard ratio (HR) = 4.224, ; 95% CI: 1.130–15.783). Plasma PTX3 levels are a long-term independent predictor of prognosis in patients with CHF.