Gene Network Analysis of Glucose Linked Signaling Pathways and Their Role in Human Hepatocellular Carcinoma Cell Growth and Survival in HuH7 and HepG2 Cell Lines

Table 1

Datasets retrieved from the literature and used to build phenotype sets.

	Data source	Genes number	Genes with; intracellular pathway	Genes with; transcription factor
			(%)	(%)
Genome	FatiGo+ database	31524
Detected in HepG2	Microarray data analysis [12]	20839	11705 (56%)	10477 (50%)
Liver	Microarray data analysis [12]	4918	1631 (33%)	1676 (34%)
HCC	Microarray data analysis [12]	806	516 (64%)	560 (69%)
Cancer biomarkers	Genes representing cancer biomarkers [70]	1262	755 (60%)	815 (65%)
Deregulated in HepG2 versus HuH7	Common genes from:	213	146 (69%)	132 (62%)
	(i) Comparative analysis of human cell lines [28]
	(ii) Comparative analysis of liver cell lines [29]
High glucose	(i) Common genes from:	447	307 (69%)	336 (75%)
	(a) Aortic cells [71]
	(b) Leukocytes (GSE32909)
	(c) Vascular smooth muscle (GSE17556)
	(ii) HepG2 [27]	129	98 (76%)	124 (96%)