Association between ANKK1 (rs1800497) and LTA (rs909253) Genetic Variants and Risk of Schizophrenia
Table 1
Sociodemographic and clinical information of schizophrenia patients.
Parameter
Schizophrenia cases ()
(95% confidence interval)
Ratio of women : men
48 : 72 (1 : 1.5)
Ratio of urban : rural residence
60 : 60 (1 : 1)
Number (%) with family history (+)a,b
36 (30)c
146.8 (0.2–0.4)d
Age at onset (years)
27.6 ± 10.9
27.7 (25.6–29.6)d
Age at examination (range, years)e
32.6 ± 11.27 (20–55)
31.6 (30.6–34.6)d
Duration of disease (years)
9.8 ± 4.7
22.7 (9.0–10.6)d
Number (%) with acute onset
46 (38)
Number (%) with insidious onset
74 (62)
PANSS score
Total
92.8 ± 13.56
74.7 (90.3–95.3)d
Positive
23.1 ± 4.52
56.1 (22.3–23.9)d
Negative
22.7 ± 4.16
59.1 (21.9–23.5)d
General psychopathology
47.8 ± 7.79
67.1 (46.4–49.2)d
Antipsychotic medication
Typical
84 (70%)c
342.8 (0.6–0.8)d
Atypical
36 (30%)c
146.8 (0.2–0.4)d
Typical-atypical
48 (40%)c
195.8 (0.3–0.5)d
PANSS: Positive and Negative Syndrome Scale; SD: standard deviation. Number of patients, with percentages in parentheses. bFamily history was considered positive (+) if there was more than one case having schizophrenia in the same family and negative (−) if the case was sporadic. c-value’s test. dVery highly significant difference (< 0.0001). eStudent’s -test. Values are mean ± standard deviation.
