Association between ANKK1 (rs1800497) and LTA (rs909253) Genetic Variants and Risk of Schizophrenia

Table 4

Distribution of ANKK1 rs1800497 (T>C) genotypes and their allelic frequencies in schizophrenia cases and controls from different ethnic populations.

Population^a (ethnicity)	Number of cases (controls)	Distribution of rs1800497 genotypes (%)^b			C allele frequency in cases (controls)	Odds ratio (95% CI)	value	Reference
		TT	TC	CC
American (non-Hispanic white)	87 (69)	2.3 (0.0)	31.0 (14.5)	66.7 (85.5)	0.82 (0.93)	0.4 (0.2–0.8)	0.008^c	[21]
Egyptian (African Arab)	120 (100)	0.0 (12.0)	35.8 (33.0)	64.2 (55.0)	0.82 (0.72)	1.8 (1.2–2.9)	0.009^c	This study
French (Caucasian)	144 (142)	4.2 (6.3)	30.6 (38.0)	65.3 (55.6)	0.81 (0.75)	1.5 (1.1–2.2)	0.019^c	[38]
Brazilian (Latino)	235 (834)	12.4 (16.6)	47.6 (48.8)	40.0 (34.7)	0.64 (0.59)	1.2 (1.0–1.5)	0.062^d	[16]
Russian (Caucasian)	311 (364)	5.8 (2.7)	33.4 (31.9)	60.8 (65.4)	0.78 (0.81)	0.8 (0.6–1.0)	0.083^d	[42]
Indian (Indian)	212 (194)	8.0 (15.0)	44.0 (40.0)	48.0 (45.0)	0.70 (0.65)	1.3 (0.9–1.7)	0.141^d	[41]
Chinese (East Asian)	396 (399)	16.4 (12.8)	45.7 (46.9)	37.9 (40.3)	0.61 (0.64)	0.9 (0.7–1.1)	0.209^d	[43]
Iranian (Sri Lankan)	38 (63)	15.8 (4.8)	55.3 (61.9)	28.9 (33.3)	0.57 (0.64)	0.7 (0.4–1.3)	0.276^d	[36]
French (Caucasian)	62 (161)	3.2 (3.1)	30.6 (28.0)	66.1 (68.9)	0.87 (0.85)	0.9 (0.5–1.5)	0.712^d	[40]
German (Caucasian)	60 (60)	3.3 (1.7)	30.0 (30.0)	66.7 (68.3)	0.82 (0.83)	0.9 (0.5–1.7)	0.734^d	[39]

ANKK1: ankyrin repeat and kinase domain containing 1; SNP: single-nucleotide polymorphism.
Populations are arranged in ascending order of the values.
^bGenotype distributions of schizophrenia cases, with distributions of controls in parentheses.
^cThe distribution of the ANKK1 rs1800497 C allele is significantly different between schizophrenia cases and controls ( < 0.05).
^dThe distribution of the ANKK1 rs1800497 C allele does not differ between schizophrenia cases and controls ( > 0.05).