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BioMed Research International
Volume 2015, Article ID 823620, 12 pages
http://dx.doi.org/10.1155/2015/823620
Review Article

MicroRNAs as Regulator of Signaling Networks in Metastatic Colon Cancer

1Human Stem Cell Institute of the General Hospital, Ningxia Medical University, Yinchuan 750004, China
2Department of Colorectal Surgery, The General Hospital of Ningxia Medical University, Yinchuan 750004, China
3Department of Clinical Oncology, Queen Elizabeth Hospital, Kowloon, Hong Kong

Received 2 February 2015; Revised 6 April 2015; Accepted 6 April 2015

Academic Editor: Yun Yen

Copyright © 2015 Jian Wang et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

MicroRNAs (miRNAs) are a class of small, noncoding RNA molecules capable of regulating gene expression translationally and/or transcriptionally. A large number of evidence have demonstrated that miRNAs have a functional role in both physiological and pathological processes by regulating the expression of their target genes. Recently, the functionalities of miRNAs in the initiation, progression, angiogenesis, metastasis, and chemoresistance of tumors have gained increasing attentions. Particularly, the alteration of miRNA profiles has been correlated with the transformation and metastasis of various cancers, including colon cancer. This paper reports the latest findings on miRNAs involved in different signaling networks leading to colon cancer metastasis, mainly focusing on miRNA profiling and their roles in PTEN/PI3K, EGFR, TGF, and p53 signaling pathways of metastatic colon cancer. The potential of miRNAs used as biomarkers in the diagnosis, prognosis, and therapeutic targets in colon cancer is also discussed.