MicroRNAs as Regulator of Signaling Networks in Metastatic Colon Cancer

Figure 1

An illustration represents the overview of microRNAs (miRNAs) and their targets involving the key signaling pathways in metastatic colon cancer. The depicted miRNAs affect important factors of colon cancer development and malignancy, such as PTEN/PDCD4, EGFR/KRAS, EGFR/mTOR, TGF, p53, and EMT transcription factors. miRNAs are able to regulate gene expressions and target the signaling pathways for controlling the proliferation, metastasis, chemoresistance, and survival of colon cancer cells. miRNAs that are labeled in red fonts are oncomirs upregulated in colon cancer; whereas miRNAs that labeled in green fonts are tumor suppressor miRNAs downregulated in colon cancer.