MicroRNAs as Regulator of Signaling Networks in Metastatic Colon Cancer

Table 1

The expressions of miRNAs and their corresponding target genes involved in metastatic colon cancer.

MicroRNA	Up/; down	Target gene(s)	References
let-7	Down	RAS, HMGA2	[83, 84]
miR-101b	Down	COX2	[85]
miR-124a	Down	CDK6, Rb	[86]
miR-133b	Down	c-Met, K-Ras, TAp63	[87]
miR-137	Down	Cdc42, LSD-1, TGF2I	[88]
miR-192	Down	DHFR, p53	[89]
miR-212		MnSOD	[90]
miR-27a	Down	SGPP1, Smad2	[91]
miR-214	Down	TP53, β-catenin, TGFR2, BAX, CDKN2b, EGFR, TFAP2C	[23]
miR-449b	Down	E2F3, CCND1	[61]
miR-497	Down	IGF1R	[13]
miR-103	Up	DAPK, KLF4	[16]
miR-107	Up	DAPK, KLF4	[16]
miR-122	Up	CAT1, ADAM17, cyclin-G, Bcl-W	[92, 93]
miR-155	Up	MSH2, MSH6, MCH1, AKT	[74, 94]
miR-182	Up	ENTPD5, IGFR1, FoxF2	[95, 96]
miR-210	Up	K-Ras, Bcl-2	[12, 97]
miR-221	Up	c-Kit, Stat5A, ETS1, ENOS	[12, 18]
miR-451	Up	MIF, IL6R	[98]
miR-675	Up	RB	[99]