In Vitro Inhibitory and Cytotoxic Activity of MFM 501, a Novel Codonopsinine Derivative, against Methicillin-Resistant Staphylococcus aureus Clinical Isolates

Table 1

Inhibitory activity of codonopsinine derivatives against a panel of S. aureus isolates.

Compounds	MIC (μg/mL)
	N441	U949	ATCC 25923	ATCC 33591
1b–5b	>1000	>1000	>1000	>1000
6c–11c	>1000	>1000	>1000	>1000
12e–15e	>1000	>1000	>1000	>1000
16e	125	125	250	125
17e-18e	>1000	>1000	>1000	>1000
19e	500	500	1000	500
20e–25e	>1000	>1000	>1000	>1000
26e	125	250	250	125
27e	>1000	>1000	>1000	>1000
MFM 501	31.3	31.3	31.3	31.3
Oxacillin	500	500	0.24	250
Vancomycin	1.56	1.56	0.78	3.13