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BioMed Research International
Volume 2015, Article ID 824746, 14 pages
http://dx.doi.org/10.1155/2015/824746
Research Article

Encapsulation of Curcumin in Diblock Copolymer Micelles for Cancer Therapy

1Cancer Research Center, Tehran University of Medical Sciences, Tehran 14197-33141, Iran
2Department of Genetics, School of Biological Sciences, Tarbiat Modares University, Tehran 14115-137, Iran
3Department of Resin and Additives, Institute for Color Science and Technology, Tehran 16765-654, Iran
4Immunology Lab, Institute of Biochemistry and Biophysics, University of Tehran, Tehran 13145-1384, Iran
5Department of Biotechnology, Faculty of Advanced Medical Technology, Golestan University of Medical Sciences, Gorgan 49175-553, Iran
6Department of Pathology, School of Medicine, Tehran University of Medical Sciences, Tehran 14197-33141, Iran
7School of Biological Science, Damghan University, Damghan 36716-41167, Iran
8Cancer Model Research Center, Tehran University of Medical Sciences, Tehran 14197-33141, Iran

Received 9 June 2014; Revised 22 October 2014; Accepted 23 October 2014

Academic Editor: Bruno C. Cavalcanti

Copyright © 2015 Ali Mohammad Alizadeh et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Application of nanoparticles has recently promising results for water insoluble agents like curcumin. In this study, we synthesized polymeric nanoparticle-curcumin (PNPC) and then showed its efficiency, drug loading, stability, and safety. Therapeutic effects of PNPC were also assessed on two cell lines and in an animal model of breast cancer. PNPC remarkably suppressed mammary and hepatocellular carcinoma cells proliferation (). Under the dosing procedure, PNPC was safe at 31.25 mg/kg and lower doses. Higher doses demonstrated minimal hepatocellular and renal toxicity in paraclinical and histopathological examinations. Tumor take rate in PNPC-treated group was 37.5% compared with 87.5% in control (). Average tumor size and weight were significantly lower in PNPC group than control (). PNPC increased proapoptotic Bax protein expression (). Antiapoptotic Bcl-2 protein expression, however, was lower in PNPC-treated animals than the control ones (). In addition, proliferative and angiogenic parameters were statistically decreased in PNPC-treated animals (). These results highlight the suppressing role for PNPC in in vitro and in vivo tumor growth models. Our findings provide credible evidence for superior biocompatibility of the polymeric nanocarrier in pharmacological arena together with an excellent tumor-suppressing response.