Cosuppression of Sprouty and Sprouty-Related Negative Regulators of FGF Signalling in Prostate Cancer: A Working Hypothesis
Analysis of (a) SPRY1, (b) SPRY2, (c) SPRED1, and (d) SPRED2 gene expression in Affymetrix gene chip hybridisation of mRNA (GEO dataset GDS1439; ) from benign prostatic hyperplasia (benign, ), primary prostate carcinoma tissue (primary, ), and metastatic prostate cancer (metastatic, ). Individual data points are given with means (sem) indicated by bar and whiskers of the MAS5-calculated signal intensity where the greater intensity indicates greater expression. Significant differences between means determined by one way ANOVA and Tukey’s HSD post hoc test, where and . (e) Analysis of mean (sem) sums of each gene rank score for individual samples, according to pathology, for association by rank correlation.