Diagnostic Value of Subjective Memory Complaints Assessed with a Single Item in Dominantly Inherited Alzheimer’s Disease: Results of the DIAN Study
Table 2
Characteristics of the participants of the DIAN study by CDR stage and carrier status.
Variables
Mutation carriers (MCs) ()
Noncarriers (NCs) ()
value
CDR 0
Age (years)
35.1 ± 8.8
39.4 ± 10.2
0.002
Gender (M/F)
46/61
45/64
0.800
Education level (years)
14.2 ± 2.7
14.7 ± 2.7
0.092
CDR sum of boxes
0.03 ± 0.1
0.01 ± 0.08
0.186
Logical memory, delayed recall (percentile)
55.3 ± 33.2
62.2 ± 31.1
0.181
MMSE
29.0 ± 1.3
29.1 ± 1.3
0.488
GDS
1.6 ± 1.9
1.2 ± 1.5
0.129
SMCs (number)
13
10
0.478
CDR 0.5
Age (years)
42.6 ± 9.3
42.4 ± 12.4
0.774
Gender (M/F)
21/27
2/6
0.449
Education level (years)
13.4 ± 2.3
12.5 ± 3.4
0.50
CDR sum of boxes
1.5 ± 1.1
0.6 ± 0.4
0.007
Logical memory, delayed recall (percentile)
17.4 ± 27.6
44.8 ± 39.4
0.015
MMSE
26.6 ± 2.8
28.4 ± 1.6
0.09
GDS
3.7 ± 3.4
2.1 ± 2.5
0.198
SMCs (number)
32
5
1.000
CDR ≥ 1
Age (years)
48.4 ± 8.6
n.a.
Gender (M/F)
14/14
0
Education level (years)
12.8 ± 2.7
n.a.
CDR sum of boxes
7.9 ± 4.1
n.a.
Logical memory, delayed recall (percentile)
10.4 ± 27.1
n.a.
MMSE
15.6 ± 6.3
n.a.
GDS
4.1 ± 3.1
n.a.
SMCs (number)
27
0
Mann-Whitney test; Chi-square test; Fisher’s exact test; CDR denotes Clinical Dementia Rating Scale; M denotes male and F denotes female; MMSE denotes Mini-Mental Status Examination; GDS denotes Geriatric Depression Scale; age, education levels, CDR sum of boxes, MMSE, logical memory, and GDS scores are displayed in mean and standard deviation.
