HPV Infection, but Not EBV or HHV-8 Infection, Is Associated with Salivary Gland Tumours

Table 3

Expression and detection of HPV, EBV, and HHV-8 in salivary gland tumours by immunohistochemistry, CISH, and chip technology.

		Positive	Distribution of malignant cases	Distribution of benign cases	Negative	Not evaluable
HHV-8	190	1 (0.5%)	1	0	187 (98.4%)	2 (1.1%)
EBV-LMP-1	190	4 (2.1%)	3	1	183 (96.3%)	3 (1.6%)
EBER-CISH	190	1 (0.5%)	1	0	187 (98.4%)	2 (1.1%)
p16	190	17 (9%)	14	3	159 (83.5%)	14 (7.5%)
HPV (chip)	25	19 (76%)	12	7	1 (4%)	5 (20%)

Cases with strong nuclear p16 positivity and Warthin’s tumours; HHV-8, human herpes virus 8; EBV-LMP-1, Epstein-Barr virus latent membrane protein-1; EBER-CISH, Epstein-Barr virus encoded RNA-chromogenic in situ hybridization; p16, cyclin-dependent kinase inhibitor 2A; HPV, human papillomavirus.