CMP-Neu5Ac Hydroxylase Null Mice as a Model for Studying Metabolic Disorders Caused by the Evolutionary Loss of Neu5Gc in Humans

Figure 4

Networks predicted by Ingenuity Pathway Analysis in Cmah-null mice. (a) Lipid metabolism, small molecule biochemistry, and endocrine system development and function. (b) Energy production, lipid metabolism, and small molecule biochemistry. (c) Hematological system development and function, tissue morphology, and inflammatory response. (d) Cell death and survival, embryonic development, and organ development, . Red and green denote upregulation and downregulation of genes, respectively. Solid lines and dotted lines indicate direct and indirect relationships, respectively. (e) List of genes involved in networks (a)–(d). This table includes their functions, molecules, score, and focus molecules. Red and blue indicate up- and downregulated genes, respectively, which are involved in the networks.

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