Biological Roles of Resolvins and Related Substances in the Resolution of Pain

Figure 2

Endogenous biosynthetic pathways of the D-series resolvins (RvDs), maresin 1, and neuroprotectin D1. Docosahexaenoic acid (DHA) is converted into 17S-hydroperoxy-DHA (17S-HpDHA) by 15-LOX. 17S-HpDHA is further transformed into RvD1, RvD2, RvD3, RvD4, or neuroprotectin D1. DHA can be transformed by 12-LOX into 14S-hydroperoxy-DHA (14S-HpDHA), from which subsequent epoxide hydrolysis produces maresin 1.