The Sea Lamprey as an Etiological Model for Biliary Atresia

Figure 1

Liver morphology at the onset of metamorphosis. (a) Cholangiocyte proliferation (black arrows) and lymphocyte infiltration (white arrows). Collagen staining (red) is located at the basement membrane and slight thickened around proliferating bile ducts. (b) Lymphocyte infiltration (white arrows) at hepatocyte foci and extracellular spaces. (c) Hepatocyte necrosis and autolysis (solid black triangles) around the edge of the liver. (d) Dead cells and fibrotic debris (solid white triangles). Paraffin sections were stained with Picro Sirius Red (Gladstone). Scale bar: 50 μm.

(a)

(b)

(c)

(d)