The Sea Lamprey as an Etiological Model for Biliary Atresia

Figure 3

Liver morphology at metamorphic stage 3 ((a) and (b)) and in newly transformed juveniles ((c) and (d)). ((a) and (b)) Lymphocyte infiltration (white arrows) at extracellular spaces. Fibrosis (red stain) is reduced and activated macrophages (yellow cells with filopodia) are no longer present. ((c) and (d)) Collagen fibers (red stain) at the basement membrane and activated macrophages (yellow cells with filopodia) clearing the residual dead cells and fibrotic debris (black). Paraffin sections were stained with Picro Sirius Red (Gladstone). Scale bar: 50 μm.

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