The Sea Lamprey as an Etiological Model for Biliary Atresia

Figure 4

Liver morphology in small parasitic sea lampreys. (a) Steatosis (white vacuoles in hepatocytes) and macrophage recruitment and activation (yellow cells with filopodia). (b) Activated macrophages (yellow cells with filopodia) clearing fibrosis (red), hepatocyte necrosis and bile pigment accumulation (solid white triangle), lymphocyte infiltration (white arrow), and steatosis (white vacuoles in hepatocytes). (c) Collagen deposition around the basement membrane of blood vessels (red) and macrophage recruitment and activation (yellow cells with filopodia). (d) Fibrosis (red) and hepatocyte necrosis (asterisks) and bile pigment accumulation. Paraffin sections were stained with Picro Sirius Red (Gladstone). Scale bar: 50 μm.

(a)

(b)

(c)

(d)