The Sea Lamprey as an Etiological Model for Biliary Atresia

Table 1

Comparisons between human and sea lamprey biliary atresia.

	Human	Sea lamprey
Bile formation	Yes	Yes
Cholestasis	Yes	Yes
Inflammation	Yes	Yes
Fibrosis	Yes	Yes
Cirrhosis	Yes	No
Liver failure	Yes	No
Downregulation of cyp7a1 transcripts	Yes	Yes
Extrahepatic excretion sites for bile salts	Kidneys	Intestine, Kidneys, and Gills