Delivery of Nucleic Acids and Nanomaterials by Cell-Penetrating Peptides: Opportunities and Challenges

Figure 2

Reaction scheme for linking CPPs to cargoes. The cargoes can be linked to the CPPs through a covalent linkage method such as (a) bissulfosuccinimidyl suberate, (b) carbodiimide, or (c) Sulfo-SMCC with a cysteine-modified CPP, or through a noncovalent method such as (d) biotin-streptavidin interaction.

(a)

(b)

(c)

(d)