Research Article

Computer-Aided Quantification of Interstitial Lung Disease from High Resolution Computed Tomography Images in Systemic Sclerosis: Correlation with Visual Reader-Based Score and Physiologic Tests

Table 1

Criterion values and coordinates of the ROC curve.

CriterionSensitivity95% CISpecificity95% CI+LR95% CI−LR95% CI+PV95% CI−PV95% CI

5.8297.5687.1–99.95.130.6–17.31.030.9–1.10.480.04–5.065.653.9–76.153.11.6–99.1
6.5297.5687.1–99.97.691.6–20.91.061.0–1.20.320.03–2.966.254.5–76.762.98.0–98.7
7.3595.1283.5–99.412.824.3–27.41.090.9–1.30.380.08–1.867.055.0–77.558.616.8–92.4
8.1095.1283.5–99.417.957.5–33.51.161.0–1.40.270.06–1.268.356.3–78.866.525.1–94.4
9.3695.1283.5–99.423.0811.1–39.31.241.0–1.50.210.05–0.969.757.6–80.071.832.1–95.7
10.8195.1283.5–99.430.7717.0–47.61.371.1–1.70.160.04–0.771.859.6–82.177.343.5–96.0
11.4992.6880.1–98.543.5927.8–60.41.641.2–2.20.170.05–0.575.362.8–85.376.248.9–93.4
12.4187.8073.8–95.953.8537.2–69.91.901.3–2.70.230.09–0.577.965.1–87.870.446.8–88.0
13.2285.3770.8–94.466.6749.8–80.92.561.6–4.10.220.1–0.582.669.7–91.671.050.1–87.0
14.3782.9367.9–92.871.7955.1–85.02.941.7–4.90.240.1–0.584.571.7–93.169.449.2–85.3
15.1582.9367.9–92.876.9260.7–88.93.592.0–6.50.220.1–0.487.074.3–94.970.851.4–85.9
16.4378.0562.4–89.484.6269.5–94.15.072.4–10.80.260.1–0.590.477.7–97.267.549.6–82.3
17.6078.0562.4–89.487.1872.6–95.76.092.6–14.00.250.1–0.591.979.6–98.068.150.3–82.8
18.2378.0562.4–89.492.3179.1–98.410.53.4–30.50.240.1–0.495.083.4–99.369.452.1–83.4
19.1375.6159.7–87.694.8782.7–99.414.43.8–57.50.260.1–0.496.585.3–99.867.750.8–81.7
20.075.6159.7–87.697.4486.5–99.929.94.2–05.70.250.1–0.498.288.0–100.068.351.4–82.2
21.8863.4146.9–77.9100.0091.0–100.00.370.2–0.5100.089.1–100.059.544.2–73.6
23.4160.9844.5–75.8100.0091.0–100.00.390.3–0.6100.088.8–100.058.042.9–72.1
26.4253.6637.4–69.3100.0091.0–100.00.460.3–0.6100.087.2–100.053.739.4–67.7
27.2451.2235.1–67.1100.0091.0–100.00.490.4–0.7100.086.8–100.052.538.3–66.4
28.4246.3430.7–62.6100.0091.0–100.00.540.4–0.7100.085.8–100.050.136.3–63.9
29.3243.9028.5–60.3100.0091.0–100.00.560.4–0.7100.084.6–100.049.035.5–62.6
29.7741.4626.3–57.9100.0091.0–100.00.590.5–0.8100.083.9–100.047.934.6–61.4
30.4334.1520.1–50.6100.0091.0–100.00.660.5–0.8100.080.5–100.045.032.3–58.1
32.9419.518.8–34.9100.0091.0–100.00.800.7–0.9100.069.2–100.040.128.5–52.6
33.3117.077.2–32.1100.0091.0–100.00.830.7–1.0100.063.1–100.039.428.0–51.7
34.3914.635.6–29.2100.0091.0–100.00.850.8–1.0100.059.0–100.038.727.4–50.9
35.799.762.7–23.1100.0091.0–100.00.900.8–1.0100.047.8–100.037.426.4–49.4
36.367.321.5–19.9100.0091.0–100.00.930.9–1.0100.029.2–100.036.726.0–48.6
37.154.880.6–16.5100.0091.0–100.00.950.9–1.0100.015.8–100.036.125.5–47.9
39.692.440.06–12.9100.0091.0–100.00.980.9–1.0100.02.5–100.035.625.0–47.2
42.560.000.0–8.6100.0091.0–100.01.001.0–1.035.024.7–46.5