Sudden Sensorineural Hearing Loss and Polymorphisms in Iron Homeostasis Genes: New Insights from a Case-Control Study

Table 2

Gene variants distribution and associated ORs values. The ORs have been calculated comparing the number of the polymorphic homozygotes with the rest of genotypes among cases versus the controls.

Gene variant	FPN1 (SLC40A1)			Tf			HFE			HFE		HEPC (HAMP)
	−8CG			C1, C2			H63D			C282Y		−582AG
Cases	200			200			200			200		200
Controls	400			400			400			400		400
Genotypes	CC	CG	GG	C1C1	C1C2	C2C2	HH	HD	DD	CC	CY	AA	AG	GG
Cases	123	62	15	139	53	8	142	56	2	193	7	111	77	12
%	61.5	31	7.5	69.5	26.5	4	71	28	1	96.5	3.5	55.5	38.5	6
Controls	268	125	7	270	119	11	294	98	8	383	17	229	147	24
%	67	31.25	1.75	67.5	29.75	2.75	73.5	24.5	2	95.75	4.25	57.25	36.75	6
value	0.001			0.63			0.55			0.80		0.92
OR (95% CI)	4.27 (2.65–6.89)			1.39 (0.71–2.73)			0.52 (0.13–2.08)			0.82 (0.33–2.0)		1.03 (0.60–1.76)
Alleles	C	G		C1	C2		H	D		C	Y	A	G
Cases number/%	308/77	92/23		331/82.75	69/17.25		340/85	60/15		393/98.25	7/1.75	299/74.75	101/25.25
Controls number/%	661/82.6	139/17.4		659/82.4	141/17.6		686/85.7	114/14.3		783/97.9	17/2.1	605/75.6	195/24.4
value	0.02			0.94			0.79			0.83		0.79
OR (95% CI)	1.42 (1.06–1.91)			0.97 (0.71–1.34)			1.06 (0.76–1.49)			0.82 (0.34–1.99)		1.05 (0.8–1.38)