Clinical Significance of Cannabinoid Receptors CB1 and CB2 Expression in Human Malignant and Benign Thyroid Lesions

Table 1

Associations of CB1 and CB2 expression with patients’ age and gender, type of histopathology, and Ki-67 protein statement in 87 patients with thyroid lesions.

Clinicopathological characteristics	CB1 expression			CB2 expression
	Low	High	value	Low	High	value
	56 (64%)	31 (36%)		55 (63%)	32 (37%)
Age (mean SD; yrs)			0.4584			0.7620
Gender			0.5470			0.6068
Female	46 (53%)	27 (31%)		47 (54%)	26 (30%)
Male	10 (11%)	4 (5%)		8 (9%)	6 (7%)
Histopathology ()			0.0010			0.0005
Benign	35 (40%)	8 (10%)		35 (40%)	8 (9%)
Malignant	21 (24%)	23 (26%)		20 (23%)	24 (28%)
Histopathology ()			0.0097			0.0110
Hyperplastic nodules	29 (38%)	8 (10%)		30 (39%)	7 (9%)
Papillary carcinoma	20 (26%)	20 (26%)		18 (23%)	22 (29%)
Ki-67 protein statement			0.5051			0.3087
Below mean value	45 (52%)	23 (26%)		47 (54%)	21 (24%)
Over mean value	11 (12%)	8 (10%)		8 (9%)	11 (13%)