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BioMed Research International
Volume 2015, Article ID 841956, 10 pages
Research Article

Identification of Gene and MicroRNA Signatures for Oral Cancer Developed from Oral Leukoplakia

1Department of Mathematics, Shanghai University, Shanghai 200444, China
2Laboratory of Oral Biomedical Science and Translational Medicine, School of Stomatology, Tongji University, Middle Yanchang Road 399, Shanghai 200072, China
3Shanghai Tenth People’s Hospital, Middle Yanchang Road 30, Shanghai 200072, China

Received 26 July 2014; Accepted 14 October 2014

Academic Editor: Hao-Teng Chang

Copyright © 2015 Guanghui Zhu et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


In clinic, oral leukoplakia (OLK) may develop into oral cancer. However, the mechanism underlying this transformation is still unclear. In this work, we present a new pipeline to identify oral cancer related genes and microRNAs (miRNAs) by integrating both gene and miRNA expression profiles. In particular, we find some network modules as well as their miRNA regulators that play important roles in the development of OLK to oral cancer. Among these network modules, 91.67% of genes and 37.5% of miRNAs have been previously reported to be related to oral cancer in literature. The promising results demonstrate the effectiveness and efficiency of our proposed approach.