Autocrine Human Urotensin II Enhances Macrophage-Derived Foam Cell Formation in Transgenic Rabbits

Figure 4

Representative aortic atherosclerosis lesions ((a), (b)) and their quantitative analysis ((c)–(f)). The data are expressed as the mean ± SEM. for each group. Representative micrographs of the intimal lesions and the cellular components (a). The aortic sections were stained with H&E or immunohistochemically stained with Abs against macrophages or smooth muscle -actin (b). The quantitative analysis of the aortic arch lesion area and the cellular composition of the macrophages and smooth muscle cells are shown at the bottom ((c)–(f)). for each group. The data are expressed as the mean ± SEM. and versus the nontransgenic littermates. M, macrophages; SMC, smooth muscle cell; Tg, transgenic.

(a)

(b)

(c)

(d)

(e)

(f)