Review Article
Genetic Polymorphism in Extracellular Regulators of Wnt Signaling Pathway
Table 1
SNPs in the selected genes and associated clinical phenotypes.
| Gene | Chromosome | SNP ID | Geographical cohort | Phenotype | Reference |
| SOST DC1 | 7p21.1 | rs16878759 rs12699800 rs17619769 | China | Osteoporosis | [23] |
| SOST | 17q21.3 | rs851054 rs851056 | Australia | BMD and BMC at total hip | [18] |
| SOST | 17q21.3 | rs1513670 rs7220711 rs1107748 | Iceland, Denmark, and Australia | Hip BMD associated | [30] |
| SOST | 17q21.3 | rs1230399 | China | Spine, FN, trochanter, and total hip BMD | [31] |
| sFRP3 | 2q32.1 | rs288326 rs7775 | Caucasian, Spanish | Knee osteoarthritis, hip osteoarthritis | [32–34] |
| sFRP3 | 2q32.1 | rs7775 | Saudi | Breast cancer | [35] |
| DKK1 | 10q21 | rs1569198 | Caucasian | Hip axis length | [36] |
| DKK3 | 11p15.3 | rs6485350 | Saudi | Breast cancer | [35] |
| DKK3 | 11p15.3 | rs1472189 | Japan | Renal cancer | [37] |
| DKK4 | 8p11.1 | rs3763511 | Saudi | Breast cancer | [35] |
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