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BioMed Research International
Volume 2015 (2015), Article ID 848710, 9 pages
http://dx.doi.org/10.1155/2015/848710
Review Article

Modulation of MicroRNAs by Phytochemicals in Cancer: Underlying Mechanisms and Translational Significance

1Mitchell Cancer Institute, University of South Alabama, Mobile, AL 36604, USA
2Department of Biochemistry and Molecular Biology, University of South Alabama, Mobile, AL 36688, USA

Received 26 August 2014; Accepted 12 October 2014

Academic Editor: Fumitaka Takeshita

Copyright © 2015 Sanjeev K. Srivastava et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

MicroRNAs (miRNAs) are small, endogenous noncoding RNAs that regulate a variety of biological processes such as differentiation, development, and survival. Recent studies suggest that miRNAs are dysregulated in cancer and play critical roles in cancer initiation, progression, and chemoresistance. Therefore, exploitation of miRNAs as targets for cancer prevention and therapy could be a promising approach. Extensive evidence suggests that many naturally occurring phytochemicals regulate the expression of numerous miRNAs involved in the pathobiology of cancer. Therefore, an understanding of the regulation of miRNAs by phytochemicals in cancer, their underlying molecular mechanisms, and functional consequences on tumor pathophysiology may be useful in formulating novel strategies to combat this devastating disease. These aspects are discussed in this review paper with an objective of highlighting the significance of these observations from the translational standpoint.