Nonalcoholic Steatohepatitis: Involvement of the Telomerase and Proinflammatory Mediators

Table 2

Histological scoring system for nonalcoholic steatohepatitis.

Variable	Score	Description
Steatosis	0	None
	1	Up to 33% of acini, mainly macrovesicular
	2	34%–66% of acini, commonly mixed steatosis
	3	Over 66% of acini (panacinar), commonly mixed steatosis
Hepatocyte ballooning	0	None
	1	Occasional in zone III
	2	Obvious in zone III
	3	Marked, predominantly in zone III
	0	None
Lobular inflammation	1	Scattered neutrophils, occasional mononuclear cells, 1 or 2 foci per 20x objective
	2	Neutrophils associated with ballooned hepatocytes, mild chronic inflammation, 3 or 4 foci per 20x objective
	3	Acute and chronic inflammation, neutrophils concentrating in zone III, over 4 foci per objective
	0	None
Portal inflammation	1	Mild, some portal areas
	2	Mild to moderate, most portal areas
	3	Moderate to severe, most portal areas
	0	No fibrosis
Stage	1	Zone III perivenular, perisinusoidal (pericellular) fibrosis
	2	Stage 1 changes + periportal fibrosis
	3	Bridging fibrosis
	4	Cirrhosis

From Merat et al. [31].